Collagen I rabbit pAb
ENT-A7919
Description
| REF | ENT-A7919 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Collagen I rabbit pAb |
| Source | Rabbit |
| Applications | WB IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from Collagen I . at AA range: 1200-1217 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 135kD |
| Human Gene ID | 1278 |
| Human Swiss Prot Nº | P08123/P02452 |
| Subcellular Location | Secreted, extracellular space, extracellular matrix . |
Other Name: collagen, type I, alpha 2
Background: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],