Cleaved-Thrombin APII (R327) rabbit pAb
ENT-A1681
Description
| REF | ENT-A1681 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Cleaved-Thrombin APII (R327) rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human THRB. AA range:278-327 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 19kD |
| Human Gene ID | 2147 |
| Human Swiss Prot Nº | P00734 |
| Subcellular Location | Secreted, extracellular space. |
Other Name: F2; Prothrombin; Coagulation factor II
Background: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],