CFAD (Cleaved-Ile26) rabbit pAb
ENT-A15512
Description
| REF | ENT-A15512 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CFAD (Cleaved-Ile26) rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human CFAD (Cleaved-Ile26) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 25kD |
| Human Gene ID | 1675 |
| Human Swiss Prot Nº | P00746 |
| Subcellular Location | Secreted. |
Other Name: Complement factor D (EC 3.4.21.46;Adipsin;C3 convertase activator;Properdin factor D)
Background: catalytic activity:Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.,disease:Defects in CFD are the cause of complement factor D deficiency [MIM:134350]. This deficiency predisposes to invasive meningococcal disease.,function:Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.,online information:CFD mutation db,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,