Cdc25A (phospho Ser178) rabbit pAb
ENT-A7789
Description
| REF | ENT-A7789 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Cdc25A (phospho Ser178) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDC25A around the phosphorylation site of Ser178. AA range:144-193 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 59kD |
| Human Gene ID | 993 |
| Human Swiss Prot Nº | P30304 |
| Subcellular Location | intracellular,nucleus,nucleoplasm,cytoplasm,cytosol, |
Other Name: CDC25A; M-phase inducer phosphatase 1; Dual specificity phosphatase Cdc25A
Background: cell division cycle 25A(CDC25A) Homo sapiens CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],