CD5 Mouse mAb
ENT-A1450
Description
| Ref | ENT-A1450 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | CD5 molecule, LEU1, Lymphocyte antigen T1/Leu 1, T1 |
| Application | IHC |
| Source | Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | IHC 1:100-200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | |
| Human Gene ID | 921 |
| Human Swiss Prot No | P06127 |
| Subcellular Location | Membrane |
Background: CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.