CD23 Mouse mAb
ENT-A1429
Description
| Ref | ENT-A1429 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | BLAST 2, CD23A, CLEC4J, Fc epsilon RII, FCE2, FCER2, IGEBF, Lymphocyte IgE receptor |
| Application | IHC |
| Source | Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | IHC 1:200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 28,38,49kDa |
| Human Gene ID | 2208 |
| Human Swiss Prot No | P06734 |
| Subcellular Location | Cell membrane. Secreted |
Background: The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils.