CD10 Rabbit pAb
ENT-A1344
Description
| REF | ENT-A1344 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CD10 Rabbit pAb |
| Source | Rabbit |
| Applications | IHC |
| Reactivity | Human, Rat, Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | IHC 1:200-500 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 85kDa |
| Human Gene ID | 4311 |
| Human Swiss Prot Nº | P08473 |
| Subcellular Location | Cell membrane |
Other Name: CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody
Background: CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer’s disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.