Caspase 10 (p23/17, Cleaved-Val220) Rabbit pAb
ENT-A14066
Description
| REF | ENT-A14066 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Caspase 10 (p23/17, Cleaved-Val220) Rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | WB 1:500-2000, ELISA(peptide)1:5000-20000 |
| Immunogen | Synthesized peptide derived from human Caspase 10 (p23/17, Cleaved-Val220) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 58+23kD |
| Human Gene ID | 843 |
| Human Swiss Prot Nº | Q92851 |
| Subcellular Location | cytosol,CD95 death-inducing signaling complex,ripoptosome, |
Other Name: Caspase-10 (CASP-10;EC 3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],