c-Myc (phospho Thr358) rabbit pAb
ENT-A6170
Description
| REF | ENT-A6170 |
|---|---|
| Category | Antibody Polyclonal |
| Description | c-Myc (phospho Thr358) rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;IP;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Immunohistochemistry: 1/100 – 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr358. AA range:325-374 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 50,(also ~60KD in some samples) |
| Human Gene ID | 4609 |
| Human Swiss Prot Nº | P01106 |
| Subcellular Location | Nucleus, nucleoplasm . Nucleus, nucleolus . |
Other Name: MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Background: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],