C/EBP α (phospho Thr230) rabbit pAb
ENT-A4587
Description
| REF | ENT-A4587 |
|---|---|
| Category | Antibody Polyclonal |
| Description | C/EBP α (phospho Thr230) rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human C/EBP α (phospho Thr230) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 42,also have 30kd isform |
| Human Gene ID | 1050 |
| Human Swiss Prot Nº | P49715 |
| Subcellular Location | Nucleus .; [Isoform 4]: Nucleus, nucleolus . |
Other Name: CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha
Background: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],