Bmi-1 Rabbit pAb(F270)
ENT-A16043
Description
| REF | ENT-A16043 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Bmi-1 Rabbit pAb(F270) |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human |
| Reactivity | Human |
| Dilution | WB 1:500-2000 |
| Immunogen | Recombinant Protein derived from human Bmi-1 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 37-43kD |
| Human Gene ID | 100532731 |
| Human Swiss Prot Nº | P35226 |
| Subcellular Location | Nucleus . Cytoplasm . |
Other Name: Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Background: BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],