Atm (phospho Ser1981) rabbit pAb
ENT-A7887
Description
| REF | ENT-A7887 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Atm (phospho Ser1981) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human; Mouse;Rat |
| Reactivity | Human; Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 350kD |
| Human Gene ID | 472 |
| Human Swiss Prot Nº | Q13315 |
| Subcellular Location | Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. . |
Other Name: ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],