ASPM rabbit pAb
ENT-A9898
Description
| REF | ENT-A9898 |
|---|---|
| Category | Antibody Polyclonal |
| Description | ASPM rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1230-1310 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 382kD |
| Human Gene ID | 259266 |
| Human Swiss Prot Nº | Q8IZT6 |
| Subcellular Location | Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity). . |
Other Name:
Background: This gene is the human ortholog of the Drosophila melanogaster ‘abnormal spindle’ gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011],