ASCC1 rabbit pAb
ENT-A14208
Description
| REF | ENT-A14208 |
|---|---|
| Category | Antibody Polyclonal |
| Description | ASCC1 rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human; Mouse |
| Reactivity | Human; Mouse |
| Dilution | WB 1：500-2000 |
| Immunogen | Synthesized peptide derived from human ASCC1 AA range: 289-339 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 51008 |
| Human Swiss Prot Nº | Q8N9N2 |
| Subcellular Location | Nucleus . Nucleus speckle . Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage. . |
Other Name:
Background: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],