a-actinin (4A12) Mouse mAb
ENT-A1573
Description
| Ref | ENT-A1573 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody |
| Application | IHC |
| Source | Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | IHC 1:100-200 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 103kDa |
| Human Gene ID | 87 |
| Human Swiss Prot No | P12814 |
| Subcellular Location | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane |
Background: α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.