53BP1 (phospho-Ser1778) rabbit pAb
ENT-A14368
Description
| REF | ENT-A14368 |
|---|---|
| Category | Antibody Polyclonal |
| Description | 53BP1 (phospho-Ser1778) rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1:1000-2000 |
| Immunogen | Synthesized phosho peptide around human 53BP1 (Ser1778) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 213kD |
| Human Gene ID | 7158 |
| Human Swiss Prot Nº | Q12888 |
| Subcellular Location | Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at ‘Lys-15’ (H2AK15Ub) and histone H4 dimethylated at ‘Lys-20’ (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). . |
Other Name: Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Background: