β-Catenin Rabbit pAb
ENT-A1195
Description
| REF | ENT-A1195 |
|---|---|
| Category | Antibody Polyclonal |
| Description | β-Catenin Rabbit pAb |
| Source | Rabbit |
| Applications | WB, IHC |
| Reactivity | Mouse, Rat |
| Reactivity | Mouse, Rat |
| Dilution | WB 1:1,000 IHC 1:500-1,000 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 92kDa |
| Human Gene ID | 1499 |
| Human Swiss Prot Nº | P35222 |
| Subcellular Location | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Synapse |
Other Name: beta catenin, b-catenin, CTNB1, CTNNB1, FLJ25606, OTTHUMP00000162082
Background: The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.