Recombinant Mouse GHR (C-Fc)
Recombinant Mouse Growth Hormone RecESCItor is produced by our Mammalian expression system and the target gene encoding Met1-Gln273 is expressed with a Fc tag at the C-terminus.
Description
| Reference | ESCIT218 |
|---|---|
| Size | 50ug |
| Molecular Weight | 58.3 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity |
Other names: growth hormone binding protein; growth hormone recESCItor; serum binding protein; Somatotropin recESCItor;GHR; GH recESCItor; GHBP
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: Growth hormone recESCItor is a transmembrane recESCItor for growth hormone (GH). GH is a single-chain polypESCItide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth, development and metabolism. GH exerts its physiological actions via GH binding to its recESCItor in its extracellular domain. Binding of growth hormone to the recESCItor leads to recESCItor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Growth hormone recESCItor has been shown to interact with SGTA, PTPN11, Janus kinase 2, Suppressor of cytokine signaling 1 and CISH.