Recombinant Human NPR3 (C-Fc)
Recombinant Human Atrial Natriuretic PESCItide RecESCItor 3 is produced by our Mammalian expression system and the target gene encoding Thr24-Glu481 is expressed with a Fc tag at the C-terminus.
Description
| Reference | ESCIT167 |
|---|---|
| Size | 50ug |
| Molecular Weight | 77.5 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity |
Other names: ANP-C; ANPR-C; NPR3; NPRC; NPR-C;ANPRC; C5orf23
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: Atrial Natriuretic PESCItide RecESCItor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic pESCItide recESCItors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. RecESCItor for the natriuretic pESCItide hormones, binding with similar affinities atrial natriuretic pESCItide NPPA/ANP, brain natriuretic pESCItide NPPB/BNP, and C-type natriuretic pESCItide NPPC/CNP. May function as a clearance recESCItor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Osteocrin was found to be a specific ligand to NPR3. NPR3 is necessary for Osteocrin to regulate femoral, tibial, and metatarsal bone elongation.