Recombinant Human ACE-2 (C-6His)
Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a 6His tag at the C-terminus.
Description
| Reference | ESCIT135 |
|---|---|
| Size | 50ug |
| Molecular Weight | 84.63 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity | Immobilized Human ACE-2-His(Cat#C419) at 2?g/ml (100 ?l/well)can bind 2019-nCoV S Protein RBD-Fc(Cat#DRA121). The ED50 of 2019-nCoV S Protein RBD (N501Y, C-Fc)(Cat#DRA121) is 3.57 ng/ml. |
Other names: Angiotensin-Converting Enzyme 2; ACE-Related CarboxypESCItidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Redissolve:
Storage: Store at ?-70°C, stable for 6 months after receipt.
Store at ?-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
Background: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypESCItidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor dont inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.