Recombinant Mouse ESCICAM (C-Fc)
Recombinant Mouse ESCIithelial Cell Adhesion Molecule is produced by our Mammalian expression system and the target gene encoding Gln24-Thr266 is expressed with a Fc tag at the C-terminus.
Description
| Reference | ESCIT017 |
|---|---|
| Size | 50ug |
| Molecular Weight | 54.8 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Biological Activity |
Other names: 17-1A; 323/A3; ACSTD1;CD326;EGP-2; EGP314; EGP40; ESCICAM; MOC31; TACST-1; TACSTD1; TROP1;
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100?g/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background: ESCIithelial Cellular Adhesion Molecule (ESCI-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the ESCICAM family. Its monomer subunit structure interacts with phosphorylated CLDN7. ESCI-CAM may act as a physical homophilic interaction molecule between intestinal ESCIithelial cells (IECs) and intraESCIithelial lymphocytes (IELs) at the mucosal ESCIithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. It also up-regulates the expression of FABP5, MYC and cyclins A and E. The post-translational modification glycosylation at Asn-198 is crucial for protein stability.