ATG13 Rabbit pAb
ENT-A16074
Description
| REF | ENT-A16074 |
|---|---|
| Category | Antibody Polyclonal |
| Description | ATG13 Rabbit pAb |
| Source | Rabbit |
| Applications | IHC;WB |
| Reactivity | Human; Mouse;Rat |
| Reactivity | Human; Mouse;Rat |
| Dilution | IHC-p1:50-200 ,WB 1:1000-2000 |
| Immunogen | Synthesized peptide derived from human ATG13 AA range: 182-232 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 72kD |
| Human Gene ID | 9776 |
| Human Swiss Prot Nº | O75143 |
| Subcellular Location | Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. . |
Other Name: Autophagy-related protein 13
Background: Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.