Bombesin Receptor 2 rabbit pAb
ENT-A16042
Description
| REF | ENT-A16042 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Bombesin Receptor 2 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF |
| Reactivity | Rat;Mouse |
| Reactivity | Rat;Mouse |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | Synthetic Peptide of Bombesin Receptor 2 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 50-70kD |
| Human Gene ID | 2925 |
| Human Swiss Prot Nº | |
| Subcellular Location |
Other Name: YM3490
Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.