Endothelin B Receptor rabbit pAb
ENT-A16013
Description
| REF | ENT-A16013 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Endothelin B Receptor rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human;Rat;Mouse |
| Reactivity | Human;Rat;Mouse |
| Dilution | IHC 1:100-200 |
| Immunogen | Synthetic Peptide of Endothelin B Receptor AA range: 270-350 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 50kD |
| Human Gene ID | 1910 |
| Human Swiss Prot Nº | P24530 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein. internalized after activation by endothelins. . |
Other Name: Endothelin B receptor (ET-B;ET-BR;Endothelin receptor non-selective type)
Background: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],