ERK1 Rabbit rabbit pAb
ENT-A16011
Description
| REF | ENT-A16011 |
|---|---|
| Category | Antibody Polyclonal |
| Description | ERK1 Rabbit rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 500-2000 IHC-p 1:50-300 |
| Immunogen | Recombinant Protein of ERK1 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 44kD |
| Human Gene ID | 5594 |
| Human Swiss Prot Nº | P27361 |
| Subcellular Location | Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). . |
Other Name: Mitogen-activated protein kinase 3 (MAP kinase 3;MAPK 3;EC 2.7.11.24;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p44-ERK1)
Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],