GABA B Receptor 2 rabbit pAb
ENT-A16002
Description
| REF | ENT-A16002 |
|---|---|
| Category | Antibody Polyclonal |
| Description | GABA B Receptor 2 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human;Rat;Mouse |
| Reactivity | Human;Rat;Mouse |
| Dilution | IHC 1:100-200 |
| Immunogen | Synthetic Peptide of GABA B Receptor 2 AA range: 785-835 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 106kD |
| Human Gene ID | 9568 |
| Human Swiss Prot Nº | O75899 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane. . |
Other Name: GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20
Background: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010],