p21 (Acetyl Lys154) rabbit pAb
ENT-A15649
Description
| REF | ENT-A15649 |
|---|---|
| Category | Antibody Polyclonal |
| Description | p21 (Acetyl Lys154) rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human p21 (Acetyl Lys154) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 21kD |
| Human Gene ID | 1026 |
| Human Swiss Prot Nº | P38936 |
| Subcellular Location | Cytoplasm . Nucleus . |
Other Name: Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21)
Background: function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,