CaMK2 (Phospho-Thr286) Rabbit pAb
ENT-A14076
Description
| REF | ENT-A14076 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CaMK2 (Phospho-Thr286) Rabbit pAb |
| Source | Rabbit |
| Applications | WB; ELISA |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | WB 1:500-2000, ELISA(peptide)1:5000-20000 |
| Immunogen | Synthesized pospho peptide derived from human CaMK2 (Phospho-Thr286) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 54kD |
| Human Gene ID | 817 |
| Human Swiss Prot Nº | Q9UQM7/Q13557 |
| Subcellular Location | Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, dendrite . Postsynaptic lipid rafts. . |
Other Name: Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta;CaMK-II subunit delta;EC 2.7.11.17)
Background: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008],