CD44 rabbit pAb
ENT-A13979
Description
| REF | ENT-A13979 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CD44 rabbit pAb |
| Source | Rabbit |
| Applications | IF;WB;IHC;ELISA |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | IF: 1:50-200 WB 1:500-2000, IHC 1:50-300 |
| Immunogen | Synthesized peptide derived from human CD44 AA range: 1105-1165 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 120kD |
| Human Gene ID | 960 |
| Human Swiss Prot Nº | P16070 |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. . |
Other Name: CD44 antigen (CDw44;Epican;Extracellular matrix receptor III;ECMR-III;GP90 lymphocyte homing/adhesion receptor;HUTCH-I;Heparan sulfate proteoglycan;Hermes antigen;Hyaluronate receptor;Phagocytic glycoprotein 1;PGP-1;Phagocytic glycoprotein I;PGP-I;CD antigen CD44)
Background: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008],