CENP-M rabbit pAb
ENT-A13953
Description
| REF | ENT-A13953 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CENP-M rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;WB |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | IHC-p 1:50-200, WB 1:500-2000 |
| Immunogen | Synthesized peptide derived from human CENP-M AA range: 30-110 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 20kD |
| Human Gene ID | 79019 |
| Human Swiss Prot Nº | Q9NSP4 |
| Subcellular Location | Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. . |
Other Name: Centromere protein M (CENP-M;Interphase centromere complex protein 39;Proliferation-associated nuclear element protein 1)
Background: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],