Desmoplakin (phospho-Ser165/166) rabbit pAb
ENT-A13656
Description
| REF | ENT-A13656 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Desmoplakin (phospho-Ser165/166) rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:1000-2000 |
| Immunogen | Synthesized phosho peptide around human Desmoplakin (Ser165 and 166) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 300kD |
| Human Gene ID | 1832 |
| Human Swiss Prot Nº | P15924 |
| Subcellular Location | Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069). Localizes at the intercalated disk in cardiomyocytes (By similarity). . |
Other Name: Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Background: This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],