p95/NBS1 (phospho-Ser343) rabbit pAb
ENT-A12493
Description
| REF | ENT-A12493 |
|---|---|
| Category | Antibody Polyclonal |
| Description | p95/NBS1 (phospho-Ser343) rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:1000-2000 |
| Immunogen | Synthesized phosho peptide around human p95 (Ser343) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 85kD |
| Human Gene ID | 4683 |
| Human Swiss Prot Nº | O60934 |
| Subcellular Location | Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of ‘Lys-5’ of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). . |
Other Name: Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)
Background: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],