PNK1 (phospho-Ser114/Thr118) rabbit pAb
ENT-A12357
Description
| REF | ENT-A12357 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PNK1 (phospho-Ser114/Thr118) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized phosho peptide around human PNK1 (Ser114 and Thr118) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 57kD |
| Human Gene ID | 11284 |
| Human Swiss Prot Nº | Q96T60 |
| Subcellular Location | Nucleus . Chromosome . Localizes to site of double-strand breaks. . |
Other Name: Bifunctional polynucleotide phosphatase/kinase (DNA 5′-kinase/3′-phosphatase) (Polynucleotide kinase-3′-phosphatase) [Includes: Polynucleotide 3′-phosphatase (EC 3.1.3.32) (2′(3′)-polynucleotidase); Polynucleotide 5′-hydroxyl-kinase (EC 2.7.1.78)]
Background: This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5′ phosphorylation and 3′ dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010],