PSMD8 rabbit pAb
ENT-A12274
Description
| REF | ENT-A12274 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PSMD8 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human; Mouse |
| Reactivity | Human; Mouse |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from human PSMD8 AA range: 1-51 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 5714 |
| Human Swiss Prot Nº | P48556 |
| Subcellular Location | proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,proteasome accessory complex,extracellular exosome, |
Other Name:
Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008],