Rb (phospho-Ser807/811) rabbit pAb
ENT-A12217
Description
| REF | ENT-A12217 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Rb (phospho-Ser807/811) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthesized phosho peptide around human Rb (Ser807 and 811) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 106kD |
| Human Gene ID | 5925 |
| Human Swiss Prot Nº | P06400 |
| Subcellular Location | Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. . |
Other Name: Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],