SIAH1 rabbit pAb
ENT-A11949
Description
| REF | ENT-A11949 |
|---|---|
| Category | Antibody Polyclonal |
| Description | SIAH1 rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human;Rat |
| Reactivity | Human;Rat |
| Dilution | WB 1：500-2000 |
| Immunogen | Synthesized peptide derived from human SIAH1 AA range: 157-207 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 6477 |
| Human Swiss Prot Nº | Q8IUQ4 |
| Subcellular Location | Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear. |
Other Name:
Background: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson’s disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],