Trk A (Phospho-Y496) Rabbit pAb
ENT-A11601
Description
| REF | ENT-A11601 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Trk A (Phospho-Y496) Rabbit pAb |
| Source | Rabbit |
| Applications | WB; IF; ELISA |
| Reactivity | Human; Mouse; Rat |
| Reactivity | Human; Mouse; Rat |
| Dilution | WB 1:500-2000; IF/ICC 1:100-500; ELISA 1:5000-20000 |
| Immunogen | Synthesized pospho peptide derived from human Trk A (Phospho-Y496) |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 180kD |
| Human Gene ID | 4914 |
| Human Swiss Prot Nº | P04629 |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. . |
Other Name: High affinity nerve growth factor receptor (EC 2.7.10.1;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;Trk-A;gp140trk;p140-TrkA)
Background: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],