FPR2 rabbit pAb
ENT-A10719
Description
| REF | ENT-A10719 |
|---|---|
| Category | Antibody Polyclonal |
| Description | FPR2 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Rat;Mouse;;Swine |
| Reactivity | Human;Rat;Mouse;;Swine |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 130-210 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 38kD |
| Human Gene ID | 2358 |
| Human Swiss Prot Nº | P25090 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011). . |
Other Name:
Background: function:Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.,