PINK1 rabbit pAb
ENT-A10253
Description
| REF | ENT-A10253 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PINK1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 63kD |
| Human Gene ID | 65018 |
| Human Swiss Prot Nº | Q9BXM7 |
| Subcellular Location | Mitochondrion outer membrane ; Single-pass membrane protein . Mitochondrion inner membrane ; Single-pass membrane protein . Cytoplasm, cytosol . Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105). When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282). . |
Other Name:
Background: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008],