3BP1 rabbit pAb
ENT-A9541
Description
| REF | ENT-A9541 |
|---|---|
| Category | Antibody Polyclonal |
| Description | 3BP1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 170-250 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 77kD |
| Human Gene ID | 23616 |
| Human Swiss Prot Nº | Q9Y3L3 |
| Subcellular Location | Cell projection . Cell junction, tight junction . Cell junction, adherens junction . Cell projection, phagocytic cup . Nucleus . Cytoplasm, cytosol . Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). . |
Other Name:
Background: function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.,sequence caution:Translated as Cys.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,