CHD8 rabbit pAb
ENT-A8836
Description
| REF | ENT-A8836 |
|---|---|
| Category | Antibody Polyclonal |
| Description | CHD8 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | IHC-p 1:50-300 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 283kD |
| Human Gene ID | 57680 |
| Human Swiss Prot Nº | Q9HCK8 |
| Subcellular Location | Nucleus . Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. . |
Other Name:
Background: This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],