PTRF rabbit pAb
ENT-A8316
Description
| REF | ENT-A8316 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PTRF rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 42kD |
| Human Gene ID | 284119 |
| Human Swiss Prot Nº | Q6NZI2 |
| Subcellular Location | Membrane, caveola . Cell membrane . Microsome . Endoplasmic reticulum . Cytoplasm, cytosol . Mitochondrion . Nucleus . Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity). . |
Other Name:
Background: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrop