Parathyroid hormone/parathyroid hormone-related peptide receptor rabbit pAb
ENT-A7989
Description
| REF | ENT-A7989 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Parathyroid hormone/parathyroid hormone-related peptide receptor rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Rat;Mouse; |
| Reactivity | Human;Rat;Mouse; |
| Dilution | WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
| Immunogen | Synthetic peptide from human protein at AA range: 46-122 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 66kD |
| Human Gene ID | 5745 |
| Human Swiss Prot Nº | Q03431 |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . |
Other Name: Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor;PTH/PTHr receptor;Parathyroid hormone 1 receptor;PTH1 receptor)
Background: The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen’s metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010],