PI 3 Kinase Class 3 rabbit pAb
ENT-A7912
Description
| REF | ENT-A7912 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PI 3 Kinase Class 3 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Mouse;Rat;Predicted:Cow:PIG |
| Reactivity | Human;Mouse;Rat;Predicted:Cow:PIG |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | Synthetic Peptide of PI 3 Kinase Class 3 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 100kD |
| Human Gene ID | 5289 |
| Human Swiss Prot Nº | Q8NEB9 |
| Subcellular Location | Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). . |
Other Name: phosphoinositide-3-kinase, class 3
Background: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.,