SKI-1 rabbit pAb
ENT-A7544
Description
| REF | ENT-A7544 |
|---|---|
| Category | Antibody Polyclonal |
| Description | SKI-1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen | Synthesized peptide derived from SKI-1 . at AA range: 180-260 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 130kD |
| Human Gene ID | 8720 |
| Human Swiss Prot Nº | Q14703 |
| Subcellular Location | Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . May sort to other organelles, including lysosomal and/or endosomal compartments. . |
Other Name: MBTPS1; KIAA0091; S1P; SKI1; Membrane-bound transcription factor site-1 protease; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1
Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014],