Rb (phospho Ser249) rabbit pAb
ENT-A6785
Description
| REF | ENT-A6785 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Rb (phospho Ser249) rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser249. AA range:221-270 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 5925 |
| Human Swiss Prot Nº | P06400 |
| Subcellular Location | Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. . |
Other Name: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],