PTPα rabbit pAb
ENT-A6737
Description
| REF | ENT-A6737 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PTPα rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen | Synthesized peptide derived from PTPα . at AA range: 730-810 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 90kD |
| Human Gene ID | 5786 |
| Human Swiss Prot Nº | P18433 |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . Cell junction, focal adhesion . Localizes to focal adhesion sites following integrin engagement. . |
Other Name: PTPRA; PTPA; PTPRL2; Receptor-type tyrosine-protein phosphatase alpha; Protein-tyrosine phosphatase alpha; R-PTP-alpha
Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],