PDE4B/C/D (phospho Ser133/119/190) rabbit pAb
ENT-A6361
Description
| REF | ENT-A6361 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PDE4B/C/D (phospho Ser133/119/190) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190/53. AA range:156-205 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 76kD |
| Human Gene ID | 5144 |
| Human Swiss Prot Nº | Q07343/Q08493/Q08499 |
| Subcellular Location | [Isoform PDE4B5]: Cytoplasm . Cell membrane . |
Other Name: PDE4B; DPDE4; cAMP-specific 3′; 5′-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4C; DPDE1; cAMP-specific 3′,5′-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4D; DPDE3; cAMP-specific 3′,5′-cyclic phosphodiesterase 4D; DPDE3; PDE43
Background: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],