IL-4 rabbit pAb
ENT-A5818
Description
| REF | ENT-A5818 |
|---|---|
| Category | Antibody Polyclonal |
| Description | IL-4 rabbit pAb |
| Source | Rabbit |
| Applications | WB;Flow Cyt;ELISA |
| Reactivity | Human;Mouse |
| Reactivity | Human;Mouse |
| Dilution | WB 1:500-2000;Flow Cyt 1:50-200;ELISA 1:5000-20000 |
| Immunogen | Synthesized peptide derived from the C-terminal region of human IL-4. |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 18kD |
| Human Gene ID | 3565 |
| Human Swiss Prot Nº | P05112 |
| Subcellular Location | Secreted. |
Other Name: IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Background: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],