GCKR rabbit pAb
ENT-A5485
Description
| REF | ENT-A5485 |
|---|---|
| Category | Antibody Polyclonal |
| Description | GCKR rabbit pAb |
| Source | Rabbit |
| Applications | WB;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Glucokinase Regulator. AA range:211-260 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 68kD |
| Human Gene ID | 2646 |
| Human Swiss Prot Nº | Q14397 |
| Subcellular Location | Cytoplasm . Nucleus . Mitochondrion . Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. . |
Other Name: GCKR; Glucokinase regulatory protein; Glucokinase regulator
Background: This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008],